Selected publications
A. MOST IMPORTANT ORIGINAL ARTICLES (with reverse chronological order)
1. Katsarou A*, Papadopoulos G*, Moustakas II, Papadopetraki A, Moustogiannis A, Legaki AI, Giannousi E, Veroutis D, Kotsinas A, Gorgoulis VG, Philippou A, Koutsilieris M, Chatzigeorgiou A. Exercise alleviates liver senescence but does not outmatch the effect of dietary restriction in diet-induced MASLD. bioRxiv 2024 Dec 03; 626591.
2. Vlachogiannis NI, Legaki AI, Kassi E, Mikelis CM, Tentolouris N, Sfikakis PP, Protogerou AD, Chatzigeorgiou A. Association of Circulating Robo4 with Obesity, Hypertension and Atherosclerotic Plaque Burden. Thromb. Haemost. 2024 Nov 11. doi: 10.1055/a-2437-6308.
3. Papadopoulos G, Legaki AI, Georgila K, Vorkas P, ………… Panayotou G, Gika H, Samiotaki M, Eliopoulos AG, Chatzigeorgiou A: Integrated omics analysis for characterization of the contribution of high fructose corn syrup to non-alcoholic fatty liver disease in obesity. Metabolism. 2023 Mar 28;144:155552.
4. Chung KJ, Legaki AI, Papadopoulos G, Gercken B, Gebler J, Schwabe RF, Chavakis T, Chatzigeorgiou A. Analysis of the Role of Stellate Cell VCAM-1 in NASH Models in Mice. Int J Mol Sci. 2023 Mar 2;24(5):4813.
5. Hadjihambi A, Velliou RI, Tsialios P, Legaki AI, Chatzigeorgiou A*, Rouchota MG* Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease. J Vis Exp. 2023 Mar 24;(193). *equal last authors
6. Arida A, Legaki AI, Kravvariti E, Protogerou A, Sfikakis PP, Chatzigeorgiou A. PCSK9/LDLR System and Rheumatoid Arthritis-Related Atherosclerosis. Front Cardiovasc Med. 2021 Oct 8; 8:738764.
7. Moustakas, II, Katsarou A, Legaki AI, Pyrina I, Ntostoglou K, Papatheodoridi AM, Gercken B, Pateras IS, Gorgoulis VG, Koutsilieris M, Chavakis T, Chatzigeorgiou A: Hepatic Senescence Accompanies the Development of NAFLD in Non-Aged Mice Independently of Obesity. Int J Mol Sci 2021 Mar 25;22(7):3446.
8. Troullinaki M, Chen LS, Witt A, Pyrina I, Phieler J, Kourtzelis I, Chmelar J, Sprott D, Gercken B, Koutsilieris M, Chavakis T, Chatzigeorgiou A: Robo4-mediated pancreatic endothelial integrity decreases inflammation and islet destruction in autoimmune diabetes. FASEB J 2020 Feb;34:3336-3346.
9. Kalafati L, Kourtzelis I, Schulte-Schrepping J, Li X, Hatzioannou A, Grinenko T, Hagag E, Sinha A, Has C, Dietz S, de Jesus Domingues AM, Nati M, Sormendi S, Neuwirth A, Chatzigeorgiou A,……….Verginis P, Mitroulis I, Chavakis T: Innate Immune Training of Granulopoiesis Promotes Anti-tumor Activity. Cell 2020 Oct 29;183:771-785 e712.
10. Chatzigeorgiou A, Mitroulis I, Chrysanthopoulou A, Legaki AI, Ritis K, Tentolouris N, Protogerou AD, Koutsilieris M, Sfikakis PP: Increased Neutrophil Extracellular Traps Related to Smoking Intensity and Subclinical Atherosclerosis in Patients with Type 2 Diabetes. Thromb Haemost 2020 Nov;120 (11):1587-1589.
11. Sprott D, Poitz DM, Korovina I, Ziogas A, Phieler J, Chatzigeorgiou A, Mitroulis I, Deussen A, Chavakis T, Klotzsche-von Ameln A: Endothelial-Specific Deficiency of ATG5 (Autophagy Protein 5) Attenuates Ischemia-Related Angiogenesis. Arterioscler Thromb Vasc Biol. 2019 Jun;39(6):1137-1148.
12. Nikolakopoulou P, Chatzigeorgiou A, Kourtzelis I, Toutouna L, ……… Chrousos G, Yi CX, García-Cáceres C, Tschöp MH, Bornstein SR, Androutsellis-Theotokis A. Streptozotocin-induced β-cell damage, high fat diet, and metformin administration regulate Hes3 expression in the adult mouse brain. Sci Rep. 2018 Jul 27;8(1):11335.
13. Moysidou M, Karaliota S, Kodela E, Salagianni M, Koutmani Y, Katsouda A, Kodella K, Tsakanikas P, Ourailidou S, Andreakos E, Kostomitsopoulos N, Skokos D, Chatzigeorgiou A, Chung KJ, Bornstein S, Sleeman MW, Chavakis T, Karalis KP. CD8+ T cells in beige adipogenesis and energy homeostasis. JCI Insight. 2018 Mar 8;3(5):e95456.
14. Mitroulis I, Ruppova K, Wang B, Chen LS, Grzybek M, Grinenko T, Eugster A, Troullinaki M, Palladini A, Kourtzelis I, Chatzigeorgiou A, Schlitzer A, Beyer M, ……. Schultze JL, Wielockx B, Zamboni N, Mirtschink P, Coskun Ü, Hajishengallis G, Netea MG, Chavakis T. Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity. Cell. 2018 Jan 11;172(1-2):147-161.e12.
15. Chung KJ*, Chatzigeorgiou A*, Economopoulou M, Garcia-Martin R, …….. Hajishengallis G, Chavakis T: A self-sustained loop of inflammation-driven inhibition of beige adipogenesis in obesity. Nat. Immunol 2017;18:654-664 *equal first authors
16. von Loeffelholz C, Lieske S, Neuschäfer-Rube F, Willmes DM, Raschzok N, Sauer IM, König J, Fromm MF, Horn P, Chatzigeorgiou A, Pathe-Neuschäfer-Rube A, …….. , Chavakis T, Püschel GP, Birkenfeld AL. The human longevity gene homolog INDY and interleukin-6 interact in hepatic lipid metabolism. Hepatology. 2017 Aug;66(2):616-630.
17. Chmelar J, Chatzigeorgiou A, Chung KJ, Prucnal M, Voehringer D, Roers A, Chavakis T: No Role for Mast Cells in Obesity-Related Metabolic Dysregulation. Front Immunol 2016 Nov 24;7:524
18. Chatzigeorgiou A, Seijkens T, Zarzycka B, Engel D, Poggi M, van den Berg S, van den Berg S, ………Schally AV, Weber C, Bornstein SR, Nicolaes G, Chavakis T, Lutgens E: Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance. Proc Natl Acad Sci USA 2014 Mar 25;111:2686-2691
19. Chatzigeorgiou A, Chung KJ, Garcia-Martin R, Alexaki VI, Klotzsche-von Ameln A, Phieler J, Sprott D, …… Bornstein SR, Muders MH, Boon L, Karalis KP, Lutgens E, Chavakis T: Dual role of B7 costimulation in obesity-related nonalcoholic steatohepatitis and metabolic dysregulation. Hepatology 2014 Oct;60 (4):1196-1210
20. Chatzigeorgiou A, Kandaraki E, Piperi C, Livadas S, Papavassiliou AG, Koutsilieris M, Papalois A, Diamanti-Kandarakis E: Dietary glycotoxins affect scavenger receptor expression and the hormonal profile of female rats. J Endocrinol. 2013 Aug 29;218(3):331-7.
21. Kanczkowski W*, Chatzigeorgiou A*, Grossklaus S, Sprott D, Bornstein SR, Chavakis T: Role of the endothelial-derived endogenous anti-inflammatory factor Del-1 in inflammation-mediated adrenal gland dysfunction. Endocrinology. 2013 Mar;154(3):1181-9.
22. Phieler J, Chung KJ*, Chatzigeorgiou A*, Klotzsche-von Ameln A, ………, Mziaut H, Solimena M, Karalis KP, Economopoulou M, Lambris JD, Chavakis T. The complement anaphylatoxin C5a receptor contributes to obese adipose tissue inflammation and insulin resistance. J Immunol. 2013 Oct 15;191(8):4367-74.
23. Langer HF, Choi EY, Zhou H, Schleicher R, Chung KJ, Tang Z, Gobel K, Bdeir K, Chatzigeorgiou A, Wong C, Bhatia S, Kruhlak MJ, ……. Lambris JD, Li X, Meuth SG, Kubes P, Chavakis T: Platelets contribute to the pathogenesis of experimental autoimmune encephalomyelitis. Circ Res 2012;110:1202-1210
24. Chatzigeorgiou A*, Ellina O*, Kouyanou S, Lymberi M, Mylona-Karagianni C, Tsouvalas E, Kamper EF: Extracellular matrix-associated (GAGs, CTGF), angiogenic (VEGF) and inflammatory factors (MCP-1, CD40, IFN-gamma) in type 1 diabetes mellitus nephropathy. Clin Chem Lab Med 2012;50:167-174 *equal first authors
25. Chatzigeorgiou A, Harokopos V, Mylona-Karagianni C, Tsouvalas E, Aidinis V, Kamper EF: The pattern of inflammatory/anti-inflammatory cytokines and chemokines in type 1 diabetic patients over time. Ann Med 2010;42:426-438
B. MOST IMPORTANT REVIEWS
1. Velliou RI, Giannousi E, Ralliou C, Kassi E, Chatzigeorgiou A. Ex Vivo Tools and Models in MASLD Research. Cells. 2024 Nov 5;13(22):1827.
2. Velliou R, Legaki AI, Nikolakopoulou P, Vlachogiannis N, Chatzigeorgiou A. Liver endothelial cells in NAFLD and transition to NASH and HCC. Cell Mol Life Sci. 2023 Oct 5;80(11):314.
3. Legaki AI, Moustakas II, Sikorska M, Papadopoulos G, Velliou RI, Chatzigeorgiou A. Hepatocyte Mitochondrial Dynamics and Bioenergetics in Obesity-Related Non-Alcoholic Fatty Liver Disease. Curr Obes Rep. 2022 Sep;11(3):126-143.
4. Papatheodoridi AM, Chrysavgis L, Koutsilieris M, Chatzigeorgiou A. The Role of Senescence in the Development of Nonalcoholic Fatty Liver Disease and Progression to Nonalcoholic Steatohepatitis. Hepatology. 2020 Jan;71(1):363-374.
5. Chung KJ, Nati M, Chavakis T, Chatzigeorgiou A. Innate immune cells in the adipose tissue. Rev Endocr Metab Disord. 2018 Dec;19(4):283-292.
6. Chatzigeorgiou A, Kandaraki E, Papavassiliou AG, Koutsilieris M. Peripheral targets in obesity treatment: a comprehensive update. Obes Rev. 2014 Jun;15(6):487-503.
7. Chatzigeorgiou A, Karalis KP, Bornstein SR, Chavakis T. Lymphocytes in obesity-related adipose tissue inflammation. Diabetologia. 2012 Oct;55(10):2583-2592.
