Our research interests lie in mechanisms perturbing the homeostasis of metabolic organs during the development of obesity/diabetes-related complications and especially during non-alcoholic fatty liver disease and steatohepatitis. Specifically, we focus on the role of
i) Inflammation and immune-parenchymal cell interactions and
ii) Adaptations of parenchymal cells of metabolic organs (and mainly those of the liver e.g. hepatocytes, endothelial cells)
during nutrient/lipid overload and metabolic stress.
To do this, we use animal models of disease within the whole spectrum of obesity and NAFLD (hepatic steatosis/NASH/HCC etc.) and we study pathophysiological mechanisms by utilizing in vivo/ex vivo and in vitro tools (cell culture/co-culture systems, genetically modified mice, human samples) and by applying cutting-edge technologies of biomedical science (omics, CyTOF, spatial phenotyping etc) .